~~~ This report is generated using bear v2.2.0 for R. ~~~ Authors: Hsin-ya Lee, Yung-jin Lee College of Pharmacy, Kaohsiung Medical University Kaohsiung, Taiwan 80708 E-mail: hsinyalee@gmail.com,pkpd.taiwan@gmail.com bear's website: http://pkpd.kmu.edu.tw/bear R website: http://www.r-project.org --------------------------------------------------- Lambda_z is calculated using the Akaike information criterion (AIC) method without including the data point of (Tmax, Cmax). -------------------------------------------------------------------------- Reference --------------------------------------------------- << NCA Outputs:- Subj.# 1 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 1 0.00 0.0 0.000 0.000 2 1 0.25 36.1 4.513 1.128 3 1 0.50 125.0 24.650 10.069 4 1 0.75 567.0 111.150 71.037 5 1 1.00 932.0 298.525 240.694 6 1 1.50 1343.0 867.275 977.319 7 1 2.00 1739.0 1637.775 2350.444 8 1 3.00 1604.0 3309.275 6495.444 9 1 4.00 1460.0 4841.275 11821.444 10 1 8.00 797.0 9355.275 36253.444 11 1 12.00 383.0 11715.275 58197.444 12 1 24.00 72.0 14445.275 96141.444 <> -------------------------------------------------- subj seq prd drug time conc code 8 1 2 2 1 3 1604 2 9 1 2 2 1 4 1460 2 10 1 2 2 1 8 797 2 11 1 2 2 1 12 383 2 12 1 2 2 1 24 72 2 <> ---------------------------- R sq. = 0.9979083 Adj. R sq. (ARS) = 0.997211 AIC = -25.53606 lambda_z = 0.1498811 Cmax = 1739 Tmax = 2 Cl/F = 5.359898 Vd/F = 35.76101 T1/2(z) = 4.624648 AUC(0-t) = 14445.27 AUC(0-inf) = 14925.66 AUMC(0-t) = 96141.44 AUMC(0-inf) = 110875.7 MRT(0-t) = 6.655563 MRT(0-inf) = 7.428529 ---------------------------- << NCA Outputs:- Subj.# 1 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 1 0.00 0 0.000 0.000 2 1 0.25 29 3.625 0.906 3 1 0.50 125 22.875 9.625 4 1 0.75 567 109.375 70.594 5 1 1.00 800 280.250 223.750 6 1 1.50 1343 816.000 927.375 7 1 2.00 1650 1564.250 2256.000 8 1 3.00 1604 3191.250 6312.000 9 1 4.00 1432 4709.250 11582.000 10 1 8.00 600 8773.250 32638.000 11 1 12.00 383 10739.250 51430.000 12 1 24.00 69 13451.250 88942.000 <> -------------------------------------------------- subj seq prd drug time conc code 20 1 2 3 1 3 1604 3 21 1 2 3 1 4 1432 3 22 1 2 3 1 8 600 3 23 1 2 3 1 12 383 3 24 1 2 3 1 24 69 3 <> ---------------------------- R sq. = 0.9927114 Adj. R sq. (ARS) = 0.9902819 AIC = -19.30472 lambda_z = 0.1493362 Cmax = 1650 Tmax = 2 Cl/F = 5.749896 Vd/F = 38.50304 T1/2(z) = 4.641523 AUC(0-t) = 13451.25 AUC(0-inf) = 13913.29 AUMC(0-t) = 88942 AUMC(0-inf) = 103125.1 MRT(0-t) = 6.612174 MRT(0-inf) = 7.41198 ---------------------------- << NCA Outputs:- Subj.# 2 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 2 0.00 0.0 0.000 0.000 2 2 0.50 69.7 17.425 8.713 3 2 0.75 167.0 47.013 28.725 4 2 1.00 602.0 143.137 119.631 5 2 1.50 1023.0 549.388 653.756 6 2 2.00 1388.0 1152.138 1731.381 7 2 3.00 1481.0 2586.637 5340.881 8 2 4.00 1346.0 4000.137 10254.381 9 2 8.00 658.0 8008.137 31550.381 10 2 12.00 336.0 9996.138 50142.381 11 2 24.00 84.0 12516.138 86430.381 <> -------------------------------------------------- subj seq prd drug time conc code 32 2 1 1 1 4 1346 5 33 2 1 1 1 8 658 5 34 2 1 1 1 12 336 5 35 2 1 1 1 24 84 5 <> ---------------------------- R sq. = 0.9872877 Adj. R sq. (ARS) = 0.9809316 AIC = -13.27891 lambda_z = 0.1358311 Cmax = 1481 Tmax = 3 Cl/F = 6.090805 Vd/F = 44.84103 T1/2(z) = 5.103009 AUC(0-t) = 12516.14 AUC(0-inf) = 13134.55 AUMC(0-t) = 86430.38 AUMC(0-inf) = 105825.2 MRT(0-t) = 6.905515 MRT(0-inf) = 8.057006 ---------------------------- << NCA Outputs:- Subj.# 2 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 2 0.00 0 0.000 0.000 2 2 0.50 65 16.250 8.125 3 2 0.75 167 45.250 27.844 4 2 1.00 599 141.000 118.375 5 2 1.50 1000 540.750 643.125 6 2 2.00 1336 1124.750 1686.125 7 2 3.00 1461 2523.250 5213.625 8 2 4.00 1346 3926.750 10097.125 9 2 8.00 638 7894.750 31073.125 10 2 12.00 330 9830.750 49201.125 11 2 24.00 81 12296.750 84625.125 <> -------------------------------------------------- subj seq prd drug time conc code 43 2 1 4 1 4 1346 8 44 2 1 4 1 8 638 8 45 2 1 4 1 12 330 8 46 2 1 4 1 24 81 8 <> ---------------------------- R sq. = 0.9867601 Adj. R sq. (ARS) = 0.9801402 AIC = -13.03225 lambda_z = 0.1372281 Cmax = 1461 Tmax = 3 Cl/F = 6.207802 Vd/F = 45.2371 T1/2(z) = 5.051057 AUC(0-t) = 12296.75 AUC(0-inf) = 12887.01 AUMC(0-t) = 84625.12 AUMC(0-inf) = 103092.6 MRT(0-t) = 6.88191 MRT(0-inf) = 7.999732 ---------------------------- << NCA Outputs:- Subj.# 3 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 3 0.00 0.0 0.000 0.000 2 3 0.50 38.2 9.550 4.775 3 3 0.75 277.0 48.950 33.131 4 3 1.00 631.0 162.450 137.975 5 3 1.50 1002.0 570.700 671.475 6 3 2.00 1780.0 1266.200 1937.225 7 3 3.00 1776.0 3044.200 6381.225 8 3 4.00 1618.0 4741.200 12281.225 9 3 8.00 782.0 9541.200 37737.225 10 3 12.00 466.0 12037.200 61433.225 11 3 24.00 89.7 15371.400 107902.025 <> -------------------------------------------------- subj seq prd drug time conc code 53 3 2 2 1 3 1776.0 10 54 3 2 2 1 4 1618.0 10 55 3 2 2 1 8 782.0 10 56 3 2 2 1 12 466.0 10 57 3 2 2 1 24 89.7 10 <> ---------------------------- R sq. = 0.9974821 Adj. R sq. (ARS) = 0.9966428 AIC = -25.09376 lambda_z = 0.1427561 Cmax = 1780 Tmax = 2 Cl/F = 5.00008 Vd/F = 35.02532 T1/2(z) = 4.855463 AUC(0-t) = 15371.4 AUC(0-inf) = 15999.74 AUMC(0-t) = 107902.0 AUMC(0-inf) = 127383.8 MRT(0-t) = 7.019662 MRT(0-inf) = 7.961615 ---------------------------- << NCA Outputs:- Subj.# 3 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 3 0.00 0.0 0.000 0.000 2 3 0.50 39.2 9.800 4.900 3 3 0.75 287.0 50.575 34.256 4 3 1.00 641.0 166.575 141.287 5 3 1.50 1012.0 579.825 681.038 6 3 2.00 1800.0 1282.825 1960.537 7 3 3.00 1786.0 3075.825 6439.538 8 3 4.00 1628.0 4782.825 12374.538 9 3 8.00 792.0 9622.825 38070.537 10 3 12.00 500.0 12206.825 62742.537 11 3 24.00 90.7 15751.025 111803.337 <> -------------------------------------------------- subj seq prd drug time conc code 64 3 2 3 1 3 1786.0 11 65 3 2 3 1 4 1628.0 11 66 3 2 3 1 8 792.0 11 67 3 2 3 1 12 500.0 11 68 3 2 3 1 24 90.7 11 <> ---------------------------- R sq. = 0.9978357 Adj. R sq. (ARS) = 0.9971143 AIC = -25.89427 lambda_z = 0.1421565 Cmax = 1800 Tmax = 2 Cl/F = 4.881307 Vd/F = 34.33755 T1/2(z) = 4.875944 AUC(0-t) = 15751.03 AUC(0-inf) = 16389.05 AUMC(0-t) = 111803.3 AUMC(0-inf) = 131604.3 MRT(0-t) = 7.098163 MRT(0-inf) = 8.030009 ---------------------------- << NCA Outputs:- Subj.# 4 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 4 0.00 0.0 0.000 0.000 2 4 0.50 37.2 9.300 4.650 3 4 0.75 306.0 52.200 35.663 4 4 1.00 758.0 185.200 159.100 5 4 1.50 1124.0 655.700 770.100 6 4 2.00 1374.0 1280.200 1878.600 7 4 3.00 1129.0 2531.700 4946.100 8 4 4.00 1043.0 3617.700 8725.600 9 4 8.00 576.0 6855.700 26285.600 10 4 12.00 325.0 8657.700 43301.600 11 4 24.00 75.9 11063.100 77631.200 <> -------------------------------------------------- subj seq prd drug time conc code 75 4 1 1 1 3 1129.0 13 76 4 1 1 1 4 1043.0 13 77 4 1 1 1 8 576.0 13 78 4 1 1 1 12 325.0 13 79 4 1 1 1 24 75.9 13 <> ---------------------------- R sq. = 0.9980289 Adj. R sq. (ARS) = 0.9973718 AIC = -27.26164 lambda_z = 0.1299347 Cmax = 1374 Tmax = 2 Cl/F = 6.86858 Vd/F = 52.86179 T1/2(z) = 5.334581 AUC(0-t) = 11063.1 AUC(0-inf) = 11647.24 AUMC(0-t) = 77631.2 AUMC(0-inf) = 96146.19 MRT(0-t) = 7.017129 MRT(0-inf) = 8.254848 ---------------------------- << NCA Outputs:- Subj.# 4 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 4 0.00 0.0 0.000 0.000 2 4 0.50 37.2 9.300 4.650 3 4 0.75 226.0 42.200 28.163 4 4 1.00 748.0 163.950 142.850 5 4 1.50 1114.0 629.450 747.600 6 4 2.00 1564.0 1298.950 1947.350 7 4 3.00 1119.0 2640.450 5189.850 8 4 4.00 1133.0 3766.450 9134.350 9 4 8.00 566.0 7164.450 27254.350 10 4 12.00 285.0 8866.450 43150.350 11 4 24.00 70.9 11001.850 73879.950 <> -------------------------------------------------- subj seq prd drug time conc code 86 4 1 4 1 3 1119.0 16 87 4 1 4 1 4 1133.0 16 88 4 1 4 1 8 566.0 16 89 4 1 4 1 12 285.0 16 90 4 1 4 1 24 70.9 16 <> ---------------------------- R sq. = 0.9906477 Adj. R sq. (ARS) = 0.9875302 AIC = -19.02509 lambda_z = 0.1354312 Cmax = 1564 Tmax = 2 Cl/F = 6.941213 Vd/F = 51.25268 T1/2(z) = 5.118075 AUC(0-t) = 11001.85 AUC(0-inf) = 11525.36 AUMC(0-t) = 73879.95 AUMC(0-inf) = 90309.79 MRT(0-t) = 6.71523 MRT(0-inf) = 7.835743 ---------------------------- << NCA Outputs:- Subj.# 5 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 5 0.00 0.0 0.000 0.000 2 5 0.25 37.9 4.737 1.184 3 5 0.50 171.0 30.850 13.056 4 5 0.75 795.0 151.600 98.275 5 5 1.00 1167.0 396.850 318.681 6 5 1.50 1403.0 1039.350 1136.556 7 5 2.00 1541.0 1775.350 2433.181 8 5 3.00 1555.0 3323.350 6306.681 9 5 4.00 1292.0 4746.850 11223.181 10 5 8.00 716.0 8762.850 33015.181 11 5 12.00 412.0 11018.850 54359.181 12 5 24.00 80.1 13971.450 95557.581 <> -------------------------------------------------- subj seq prd drug time conc code 100 5 2 2 1 8 716.0 18 101 5 2 2 1 12 412.0 18 102 5 2 2 1 24 80.1 18 <> ---------------------------- R sq. = 0.999994 Adj. R sq. (ARS) = 0.9999879 AIC = -32.47575 lambda_z = 0.1368030 Cmax = 1555 Tmax = 3 Cl/F = 5.495652 Vd/F = 40.172 T1/2(z) = 5.066753 AUC(0-t) = 13971.45 AUC(0-inf) = 14556.96 AUMC(0-t) = 95557.58 AUMC(0-inf) = 113889.9 MRT(0-t) = 6.839489 MRT(0-inf) = 7.823738 ---------------------------- << NCA Outputs:- Subj.# 5 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 5 0.00 0.0 0.000 0.000 2 5 0.25 30.9 3.862 0.966 3 5 0.50 161.0 27.850 11.994 4 5 0.75 785.0 146.100 95.650 5 5 1.00 1177.0 391.350 316.369 6 5 1.50 1413.0 1038.850 1140.494 7 5 2.00 1531.0 1774.850 2435.869 8 5 3.00 1545.0 3312.850 6284.369 9 5 4.00 1282.0 4726.350 11165.869 10 5 8.00 706.0 8702.350 32717.869 11 5 12.00 402.0 10918.350 53661.869 12 5 24.00 80.1 13810.950 94140.269 <> -------------------------------------------------- subj seq prd drug time conc code 111 5 2 3 1 4 1282.0 19 112 5 2 3 1 8 706.0 19 113 5 2 3 1 12 402.0 19 114 5 2 3 1 24 80.1 19 <> ---------------------------- R sq. = 0.9995184 Adj. R sq. (ARS) = 0.9992777 AIC = -26.30072 lambda_z = 0.1378954 Cmax = 1545 Tmax = 3 Cl/F = 5.558711 Vd/F = 40.31108 T1/2(z) = 5.026617 AUC(0-t) = 13810.95 AUC(0-inf) = 14391.83 AUMC(0-t) = 94140.27 AUMC(0-inf) = 112293.7 MRT(0-t) = 6.81635 MRT(0-inf) = 7.802604 ---------------------------- << NCA Outputs:- Subj.# 6 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 6 0.00 0.0 0.000 0.000 2 6 0.50 213.0 53.250 26.625 3 6 0.75 799.0 179.750 114.844 4 6 1.00 987.0 403.000 313.125 5 6 1.50 1301.0 975.000 1047.750 6 6 2.00 1756.0 1739.250 2413.625 7 6 3.00 1665.0 3449.750 6667.125 8 6 4.00 1529.0 5046.750 12222.625 9 6 8.00 772.0 9648.750 36806.625 10 6 12.00 461.0 12114.750 60222.625 11 6 24.00 82.6 15376.350 105309.025 <> -------------------------------------------------- subj seq prd drug time conc code 121 6 1 1 1 3 1665.0 21 122 6 1 1 1 4 1529.0 21 123 6 1 1 1 8 772.0 21 124 6 1 1 1 12 461.0 21 125 6 1 1 1 24 82.6 21 <> ---------------------------- R sq. = 0.9989957 Adj. R sq. (ARS) = 0.998661 AIC = -29.62112 lambda_z = 0.1438420 Cmax = 1756 Tmax = 2 Cl/F = 5.015488 Vd/F = 34.86802 T1/2(z) = 4.818808 AUC(0-t) = 15376.35 AUC(0-inf) = 15950.59 AUMC(0-t) = 105309.0 AUMC(0-inf) = 123083.0 MRT(0-t) = 6.848766 MRT(0-inf) = 7.716515 ---------------------------- << NCA Outputs:- Subj.# 6 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 6 0.00 0.0 0.000 0.000 2 6 0.50 203.0 50.750 25.375 3 6 0.75 600.0 151.125 94.312 4 6 1.00 977.0 348.250 272.688 5 6 1.50 1301.0 917.750 1004.812 6 6 2.00 1746.0 1679.500 2365.688 7 6 3.00 1675.0 3390.000 6624.188 8 6 4.00 1539.0 4997.000 12214.688 9 6 8.00 500.0 9075.000 32526.688 10 6 12.00 451.0 10977.000 51350.688 11 6 24.00 80.6 14166.600 95429.087 <> -------------------------------------------------- subj seq prd drug time conc code 132 6 1 4 1 3 1675.0 24 133 6 1 4 1 4 1539.0 24 134 6 1 4 1 8 500.0 24 135 6 1 4 1 12 451.0 24 136 6 1 4 1 24 80.6 24 <> ---------------------------- R sq. = 0.9667908 Adj. R sq. (ARS) = 0.955721 AIC = -12.08441 lambda_z = 0.1421302 Cmax = 1746 Tmax = 2 Cl/F = 5.429734 Vd/F = 38.20253 T1/2(z) = 4.876845 AUC(0-t) = 14166.6 AUC(0-inf) = 14733.69 AUMC(0-t) = 95429.09 AUMC(0-inf) = 113029.0 MRT(0-t) = 6.736203 MRT(0-inf) = 7.671471 ---------------------------- << NCA Outputs:- Subj.# 7 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 7 0.00 0.0 0.000 0.000 2 7 0.25 72.3 9.037 2.259 3 7 0.50 15.5 20.012 5.487 4 7 0.75 403.0 72.325 44.237 5 7 1.00 1114.0 261.950 221.269 6 7 1.50 1566.0 931.950 1087.019 7 7 2.00 1488.0 1695.450 2418.269 8 7 3.00 1471.0 3174.950 6112.769 9 7 4.00 1249.0 4534.950 10817.269 10 7 8.00 657.0 8346.950 31321.269 11 7 12.00 411.0 10482.950 51697.269 12 7 24.00 82.1 13441.550 93111.669 <> -------------------------------------------------- subj seq prd drug time conc code 143 7 2 2 1 2 1488.0 26 144 7 2 2 1 3 1471.0 26 145 7 2 2 1 4 1249.0 26 146 7 2 2 1 8 657.0 26 147 7 2 2 1 12 411.0 26 148 7 2 2 1 24 82.1 26 <> ---------------------------- R sq. = 0.9978435 Adj. R sq. (ARS) = 0.9973044 AIC = -32.57856 lambda_z = 0.1346195 Cmax = 1566 Tmax = 1.5 Cl/F = 5.693376 Vd/F = 42.29235 T1/2(z) = 5.148935 AUC(0-t) = 13441.55 AUC(0-inf) = 14051.42 AUMC(0-t) = 93111.67 AUMC(0-inf) = 112278.8 MRT(0-t) = 6.927153 MRT(0-inf) = 7.990566 ---------------------------- << NCA Outputs:- Subj.# 7 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 7 0.00 0.0 0.000 0.000 2 7 0.25 71.3 8.912 2.228 3 7 0.50 16.5 19.887 5.487 4 7 0.75 413.0 73.575 45.237 5 7 1.00 1124.0 265.700 224.456 6 7 1.50 1680.0 966.700 1135.456 7 7 2.00 1498.0 1761.200 2514.456 8 7 3.00 1481.0 3250.700 6233.956 9 7 4.00 1259.0 4620.700 10973.456 10 7 8.00 500.0 8138.700 29045.456 11 7 12.00 421.0 9980.700 47149.456 12 7 24.00 81.1 12993.300 89139.856 <> -------------------------------------------------- subj seq prd drug time conc code 155 7 2 3 1 2 1498.0 27 156 7 2 3 1 3 1481.0 27 157 7 2 3 1 4 1259.0 27 158 7 2 3 1 8 500.0 27 159 7 2 3 1 12 421.0 27 160 7 2 3 1 24 81.1 27 <> ---------------------------- R sq. = 0.9818309 Adj. R sq. (ARS) = 0.9772886 AIC = -19.69244 lambda_z = 0.1346370 Cmax = 1680 Tmax = 1.5 Cl/F = 5.88423 Vd/F = 43.70442 T1/2(z) = 5.148268 AUC(0-t) = 12993.3 AUC(0-inf) = 13595.66 AUMC(0-t) = 89139.86 AUMC(0-inf) = 108070.5 MRT(0-t) = 6.860448 MRT(0-inf) = 7.948895 ---------------------------- << NCA Outputs:- Subj.# 8 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 8 0.00 0.0 0.000 0.000 2 8 0.25 29.2 3.650 0.912 3 8 0.50 145.0 25.425 10.887 4 8 0.75 282.0 78.800 46.388 5 8 1.00 727.0 204.925 163.700 6 8 1.50 1360.0 726.675 855.450 7 8 2.00 1939.0 1551.425 2334.950 8 8 3.00 1614.0 3327.925 6694.950 9 8 4.00 1238.0 4753.925 11591.950 10 8 8.00 648.0 8525.925 31863.950 11 8 12.00 392.0 10605.925 51639.950 12 8 24.00 77.3 13421.725 90995.150 <> -------------------------------------------------- subj seq prd drug time conc code 168 8 1 1 1 3 1614.0 29 169 8 1 1 1 4 1238.0 29 170 8 1 1 1 8 648.0 29 171 8 1 1 1 12 392.0 29 172 8 1 1 1 24 77.3 29 <> ---------------------------- R sq. = 0.9958381 Adj. R sq. (ARS) = 0.9944509 AIC = -22.66970 lambda_z = 0.1413797 Cmax = 1939 Tmax = 2 Cl/F = 5.72718 Vd/F = 40.5092 T1/2(z) = 4.902734 AUC(0-t) = 13421.72 AUC(0-inf) = 13968.48 AUMC(0-t) = 90995.15 AUMC(0-inf) = 107984.5 MRT(0-t) = 6.779691 MRT(0-inf) = 7.730586 ---------------------------- << NCA Outputs:- Subj.# 8 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 8 0.00 0.0 0.000 0.000 2 8 0.25 36.2 4.525 1.131 3 8 0.50 135.0 25.925 10.700 4 8 0.75 292.0 79.300 46.513 5 8 1.00 737.0 207.925 166.012 6 8 1.50 1370.0 734.675 864.013 7 8 2.00 1949.0 1564.425 2352.262 8 8 3.00 1624.0 3350.925 6737.262 9 8 4.00 1248.0 4786.925 11669.263 10 8 8.00 658.0 8598.925 32181.263 11 8 12.00 382.0 10678.925 51877.262 12 8 24.00 73.3 13410.725 89936.462 <> -------------------------------------------------- subj seq prd drug time conc code 182 8 1 4 1 8 658.0 32 183 8 1 4 1 12 382.0 32 184 8 1 4 1 24 73.3 32 <> ---------------------------- R sq. = 0.9999944 Adj. R sq. (ARS) = 0.9999888 AIC = -32.69201 lambda_z = 0.1372591 Cmax = 1949 Tmax = 2 Cl/F = 5.736925 Vd/F = 41.79633 T1/2(z) = 5.04992 AUC(0-t) = 13410.72 AUC(0-inf) = 13944.75 AUMC(0-t) = 89936.46 AUMC(0-inf) = 106643.8 MRT(0-t) = 6.706309 MRT(0-inf) = 7.64759 ---------------------------- << NCA Outputs:- Subj.# 9 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 9 0.00 0.0 0.000 0.000 2 9 0.25 33.3 4.162 1.041 3 9 0.50 118.0 23.075 9.456 4 9 0.75 320.0 77.825 46.831 5 9 1.00 1118.0 257.575 216.581 6 9 1.50 1469.0 904.325 1046.956 7 9 2.00 1475.0 1640.325 2335.331 8 9 3.00 1200.0 2977.825 5610.331 9 9 4.00 1126.0 4140.825 9662.331 10 9 8.00 645.0 7682.825 28990.331 11 9 12.00 377.0 9726.825 48358.331 12 9 24.00 70.2 12410.025 85611.131 <> -------------------------------------------------- subj seq prd drug time conc code 193 9 2 2 1 4 1126.0 34 194 9 2 2 1 8 645.0 34 195 9 2 2 1 12 377.0 34 196 9 2 2 1 24 70.2 34 <> ---------------------------- R sq. = 0.9999516 Adj. R sq. (ARS) = 0.9999274 AIC = -35.44355 lambda_z = 0.1387153 Cmax = 1475 Tmax = 2 Cl/F = 6.193821 Vd/F = 44.65131 T1/2(z) = 4.996904 AUC(0-t) = 12410.03 AUC(0-inf) = 12916.10 AUMC(0-t) = 85611.13 AUMC(0-inf) = 101405.1 MRT(0-t) = 6.898546 MRT(0-inf) = 7.851067 ---------------------------- << NCA Outputs:- Subj.# 9 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 9 0.00 0.0 0.000 0.000 2 9 0.25 34.3 4.287 1.072 3 9 0.50 128.0 24.575 10.144 4 9 0.75 310.0 79.325 47.206 5 9 1.00 1128.0 259.075 217.269 6 9 1.50 1479.0 910.825 1053.894 7 9 2.00 1885.0 1751.825 2551.019 8 9 3.00 1210.0 3299.325 6251.019 9 9 4.00 1116.0 4462.325 10298.019 10 9 8.00 625.0 7944.325 29226.019 11 9 12.00 387.0 9968.325 48514.019 12 9 24.00 65.2 12681.525 85766.819 <> -------------------------------------------------- subj seq prd drug time conc code 204 9 2 3 1 3 1210.0 35 205 9 2 3 1 4 1116.0 35 206 9 2 3 1 8 625.0 35 207 9 2 3 1 12 387.0 35 208 9 2 3 1 24 65.2 35 <> ---------------------------- R sq. = 0.998494 Adj. R sq. (ARS) = 0.9979921 AIC = -27.87038 lambda_z = 0.1399092 Cmax = 1885 Tmax = 2 Cl/F = 6.084788 Vd/F = 43.49096 T1/2(z) = 4.954263 AUC(0-t) = 12681.53 AUC(0-inf) = 13147.54 AUMC(0-t) = 85766.82 AUMC(0-inf) = 100282.1 MRT(0-t) = 6.763131 MRT(0-inf) = 7.627438 ---------------------------- << NCA Outputs:- Subj.# 10 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 10 0.00 0.0 0.000 0.000 2 10 0.25 55.9 6.987 1.747 3 10 0.50 153.0 33.100 13.056 4 10 0.75 420.0 104.725 61.994 5 10 1.00 1033.0 286.350 230.494 6 10 1.50 1388.0 891.600 1009.244 7 10 2.00 1279.0 1558.350 2169.244 8 10 3.00 1205.0 2800.350 5255.744 9 10 4.00 1113.0 3959.350 9289.244 10 10 8.00 770.0 7725.350 30513.244 11 10 12.00 438.0 10141.350 53345.244 12 10 24.00 90.1 13309.950 97855.644 <> -------------------------------------------------- subj seq prd drug time conc code 215 10 1 1 1 2 1279.0 37 216 10 1 1 1 3 1205.0 37 217 10 1 1 1 4 1113.0 37 218 10 1 1 1 8 770.0 37 219 10 1 1 1 12 438.0 37 220 10 1 1 1 24 90.1 37 <> ---------------------------- R sq. = 0.9934808 Adj. R sq. (ARS) = 0.991851 AIC = -27.06244 lambda_z = 0.1223398 Cmax = 1388 Tmax = 1.5 Cl/F = 5.6954 Vd/F = 46.55394 T1/2(z) = 5.665753 AUC(0-t) = 13309.95 AUC(0-inf) = 14046.42 AUMC(0-t) = 97855.64 AUMC(0-inf) = 121550.9 MRT(0-t) = 7.352067 MRT(0-inf) = 8.653513 ---------------------------- << NCA Outputs:- Subj.# 10 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 10 0.00 0.0 0.000 0.000 2 10 0.25 59.9 7.487 1.872 3 10 0.50 143.0 32.850 12.681 4 10 0.75 430.0 104.475 61.931 5 10 1.00 1043.0 288.600 232.619 6 10 1.50 1598.0 948.850 1092.619 7 10 2.00 1289.0 1670.600 2336.369 8 10 3.00 1215.0 2922.600 5447.869 9 10 4.00 1123.0 4091.600 9516.369 10 10 8.00 780.0 7897.600 30980.369 11 10 12.00 448.0 10353.600 54212.369 12 10 24.00 95.1 13612.200 100162.769 <> -------------------------------------------------- subj seq prd drug time conc code 227 10 1 4 1 2 1289.0 40 228 10 1 4 1 3 1215.0 40 229 10 1 4 1 4 1123.0 40 230 10 1 4 1 8 780.0 40 231 10 1 4 1 12 448.0 40 232 10 1 4 1 24 95.1 40 <> ---------------------------- R sq. = 0.9937432 Adj. R sq. (ARS) = 0.992179 AIC = -27.52143 lambda_z = 0.1202078 Cmax = 1598 Tmax = 1.5 Cl/F = 5.554271 Vd/F = 46.20560 T1/2(z) = 5.766243 AUC(0-t) = 13612.2 AUC(0-inf) = 14403.33 AUMC(0-t) = 100162.8 AUMC(0-inf) = 125731.3 MRT(0-t) = 7.358309 MRT(0-inf) = 8.729318 ---------------------------- << NCA Outputs:- Subj.# 11 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 11 0.00 0 0.000 0.000 2 11 0.25 81 10.125 2.531 3 11 0.50 213 46.875 18.375 4 11 0.75 387 121.875 67.969 5 11 1.00 1012 296.750 230.750 6 11 1.50 1127 831.500 906.375 7 11 2.00 1029 1370.500 1843.500 8 11 3.00 889 2329.500 4206.000 9 11 4.00 750 3149.000 7039.500 10 11 8.00 445 5539.000 20159.500 11 11 12.00 325 7079.000 35079.500 12 11 24.00 54 9353.000 66255.500 <> -------------------------------------------------- subj seq prd drug time conc code 239 11 2 2 1 2 1029 42 240 11 2 2 1 3 889 42 241 11 2 2 1 4 750 42 242 11 2 2 1 8 445 42 243 11 2 2 1 12 325 42 244 11 2 2 1 24 54 42 <> ---------------------------- R sq. = 0.9941775 Adj. R sq. (ARS) = 0.9927219 AIC = -26.89805 lambda_z = 0.1312836 Cmax = 1127 Tmax = 1.5 Cl/F = 8.193092 Vd/F = 62.40759 T1/2(z) = 5.279771 AUC(0-t) = 9353 AUC(0-inf) = 9764.323 AUMC(0-t) = 66255.5 AUMC(0-inf) = 79260.35 MRT(0-t) = 7.083877 MRT(0-inf) = 8.117342 ---------------------------- << NCA Outputs:- Subj.# 11 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 11 0.00 0 0.000 0.000 2 11 0.25 80 10.000 2.500 3 11 0.50 203 45.375 17.688 4 11 0.75 397 120.375 67.594 5 11 1.00 1002 295.250 230.062 6 11 1.50 1317 875.000 974.438 7 11 2.00 1019 1459.000 1977.812 8 11 3.00 899 2418.000 4345.312 9 11 4.00 760 3247.500 7213.812 10 11 8.00 455 5677.500 20573.812 11 11 12.00 315 7217.500 35413.812 12 11 24.00 50 9407.500 65293.812 <> -------------------------------------------------- subj seq prd drug time conc code 251 11 2 3 1 2 1019 43 252 11 2 3 1 3 899 43 253 11 2 3 1 4 760 43 254 11 2 3 1 8 455 43 255 11 2 3 1 12 315 43 256 11 2 3 1 24 50 43 <> ---------------------------- R sq. = 0.9950847 Adj. R sq. (ARS) = 0.9938558 AIC = -27.56783 lambda_z = 0.1351906 Cmax = 1317 Tmax = 1.5 Cl/F = 8.182178 Vd/F = 60.52328 T1/2(z) = 5.127185 AUC(0-t) = 9407.5 AUC(0-inf) = 9777.348 AUMC(0-t) = 65293.81 AUMC(0-inf) = 76905.93 MRT(0-t) = 6.940613 MRT(0-inf) = 7.865724 ---------------------------- << NCA Outputs:- Subj.# 12 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 12 0.00 0.0 0.000 0.000 2 12 0.25 112.2 14.025 3.506 3 12 0.50 169.0 49.175 17.575 4 12 0.75 532.0 136.800 78.013 5 12 1.00 759.0 298.175 222.762 6 12 1.50 1425.0 844.175 946.888 7 12 2.00 1318.0 1529.925 2140.262 8 12 3.00 1542.0 2959.925 5771.262 9 12 4.00 1386.0 4423.925 10856.263 10 12 8.00 786.0 8767.925 34520.262 11 12 12.00 511.0 11361.925 59360.262 12 12 24.00 97.9 15015.325 110249.863 <> -------------------------------------------------- subj seq prd drug time conc code 265 12 1 1 1 4 1386.0 45 266 12 1 1 1 8 786.0 45 267 12 1 1 1 12 511.0 45 268 12 1 1 1 24 97.9 45 <> ---------------------------- R sq. = 0.9987163 Adj. R sq. (ARS) = 0.9980745 AIC = -22.73448 lambda_z = 0.1318477 Cmax = 1542 Tmax = 3 Cl/F = 5.076835 Vd/F = 38.5053 T1/2(z) = 5.25718 AUC(0-t) = 15015.32 AUC(0-inf) = 15757.85 AUMC(0-t) = 110249.9 AUMC(0-inf) = 133702.1 MRT(0-t) = 7.342489 MRT(0-inf) = 8.484794 ---------------------------- << NCA Outputs:- Subj.# 12 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 12 0.00 0.0 0.000 0.000 2 12 0.25 122.2 15.275 3.819 3 12 0.50 159.0 50.425 17.575 4 12 0.75 522.0 135.550 76.450 5 12 1.00 769.0 296.925 221.512 6 12 1.50 1435.0 847.925 951.888 7 12 2.00 1328.0 1538.675 2154.012 8 12 3.00 1632.0 3018.675 5930.012 9 12 4.00 1296.0 4482.675 10970.013 10 12 8.00 786.0 8646.675 33914.012 11 12 12.00 521.0 11260.675 58994.012 12 12 24.00 98.9 14980.075 110747.613 <> -------------------------------------------------- subj seq prd drug time conc code 277 12 1 4 1 4 1296.0 48 278 12 1 4 1 8 786.0 48 279 12 1 4 1 12 521.0 48 280 12 1 4 1 24 98.9 48 <> ---------------------------- R sq. = 0.997398 Adj. R sq. (ARS) = 0.996097 AIC = -20.08347 lambda_z = 0.1289054 Cmax = 1632 Tmax = 3 Cl/F = 5.080235 Vd/F = 39.41055 T1/2(z) = 5.377175 AUC(0-t) = 14980.07 AUC(0-inf) = 15747.30 AUMC(0-t) = 110747.6 AUMC(0-inf) = 135113.0 MRT(0-t) = 7.392995 MRT(0-inf) = 8.58007 ---------------------------- << NCA Outputs:- Subj.# 13 , Seq 2 , Prd 2 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 13 0.00 0.0 0.000 0.000 2 13 0.25 80.4 10.050 2.513 3 13 0.50 170.0 41.350 15.650 4 13 0.75 385.0 110.725 62.369 5 13 1.00 864.0 266.850 206.463 6 13 1.50 1235.0 791.600 885.587 7 13 2.00 1130.0 1382.850 1913.713 8 13 3.00 983.0 2439.350 4518.212 9 13 4.00 862.0 3361.850 7716.712 10 13 8.00 508.0 6101.850 22740.713 11 13 12.00 269.0 7655.850 37324.713 12 13 24.00 75.6 9723.450 67579.113 <> -------------------------------------------------- subj seq prd drug time conc code 287 13 2 2 1 2 1130.0 50 288 13 2 2 1 3 983.0 50 289 13 2 2 1 4 862.0 50 290 13 2 2 1 8 508.0 50 291 13 2 2 1 12 269.0 50 292 13 2 2 1 24 75.6 50 <> ---------------------------- R sq. = 0.9942339 Adj. R sq. (ARS) = 0.9927923 AIC = -27.63707 lambda_z = 0.1240478 Cmax = 1235 Tmax = 1.5 Cl/F = 7.742266 Vd/F = 62.41355 T1/2(z) = 5.587741 AUC(0-t) = 9723.45 AUC(0-inf) = 10332.89 AUMC(0-t) = 67579.11 AUMC(0-inf) = 87118.69 MRT(0-t) = 6.950117 MRT(0-inf) = 8.4312 ---------------------------- << NCA Outputs:- Subj.# 13 , Seq 2 , Prd 3 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 13 0.00 0.0 0.000 0.000 2 13 0.25 76.4 9.550 2.388 3 13 0.50 160.0 39.100 14.775 4 13 0.75 395.0 108.475 61.806 5 13 1.00 854.0 264.600 205.588 6 13 1.50 1245.0 789.350 885.962 7 13 2.00 1440.0 1460.600 2072.838 8 13 3.00 1273.0 2817.100 5422.337 9 13 4.00 952.0 3929.600 9235.837 10 13 8.00 418.0 6669.600 23539.838 11 13 12.00 179.0 7863.600 34523.838 12 13 24.00 70.6 9361.200 57578.238 <> -------------------------------------------------- subj seq prd drug time conc code 300 13 2 3 1 3 1273.0 51 301 13 2 3 1 4 952.0 51 302 13 2 3 1 8 418.0 51 303 13 2 3 1 12 179.0 51 304 13 2 3 1 24 70.6 51 <> ---------------------------- R sq. = 0.932258 Adj. R sq. (ARS) = 0.9096773 AIC = -8.801004 lambda_z = 0.1357015 Cmax = 1440 Tmax = 2 Cl/F = 8.09597 Vd/F = 59.66013 T1/2(z) = 5.107881 AUC(0-t) = 9361.2 AUC(0-inf) = 9881.46 AUMC(0-t) = 57578.24 AUMC(0-inf) = 73898.32 MRT(0-t) = 6.150733 MRT(0-inf) = 7.478482 ---------------------------- << NCA Outputs:- Subj.# 14 , Seq 1 , Prd 1 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 14 0.00 0.0 0.000 0.000 2 14 0.50 64.1 16.025 8.012 3 14 0.75 406.0 74.787 50.081 4 14 1.00 627.0 203.912 166.519 5 14 1.50 880.0 580.663 653.269 6 14 2.00 1120.0 1080.662 1543.269 7 14 3.00 1598.0 2439.662 5060.269 8 14 4.00 1481.0 3979.162 10419.269 9 14 8.00 851.0 8643.163 35883.269 10 14 12.00 492.0 11329.163 61307.269 11 14 24.00 116.0 14977.163 113435.269 <> -------------------------------------------------- subj seq prd drug time conc code 312 14 1 1 1 4 1481 53 313 14 1 1 1 8 851 53 314 14 1 1 1 12 492 53 315 14 1 1 1 24 116 53 <> ---------------------------- R sq. = 0.9986937 Adj. R sq. (ARS) = 0.9980406 AIC = -22.99284 lambda_z = 0.1265462 Cmax = 1598 Tmax = 3 Cl/F = 5.033402 Vd/F = 39.77521 T1/2(z) = 5.477424 AUC(0-t) = 14977.16 AUC(0-inf) = 15893.82 AUMC(0-t) = 113435.3 AUMC(0-inf) = 142678.8 MRT(0-t) = 7.573882 MRT(0-inf) = 8.976998 ---------------------------- << NCA Outputs:- Subj.# 14 , Seq 1 , Prd 4 (Ref.)>> -------------------------------------------------------------------------- subj time conc AUC(0-t) AUMC(0-t) 1 14 0.00 0.0 0.000 0.000 2 14 0.50 60.1 15.025 7.513 3 14 0.75 416.0 74.538 50.269 4 14 1.00 517.0 191.163 153.894 5 14 1.50 870.0 537.913 609.394 6 14 2.00 1330.0 1087.912 1600.644 7 14 3.00 1688.0 2596.912 5462.644 8 14 4.00 1471.0 4176.413 10936.644 9 14 8.00 951.0 9020.413 37920.644 10 14 12.00 582.0 12086.413 67104.644 11 14 24.00 100.0 16178.413 123408.644 <> -------------------------------------------------- subj seq prd drug time conc code 323 14 1 4 1 4 1471 56 324 14 1 4 1 8 951 56 325 14 1 4 1 12 582 56 326 14 1 4 1 24 100 56 <> ---------------------------- R sq. = 0.9961806 Adj. R sq. (ARS) = 0.994271 AIC = -18.10070 lambda_z = 0.1362393 Cmax = 1688 Tmax = 3 Cl/F = 4.730253 Vd/F = 34.72019 T1/2(z) = 5.08772 AUC(0-t) = 16178.41 AUC(0-inf) = 16912.42 AUMC(0-t) = 123408.6 AUMC(0-inf) = 146412.3 MRT(0-t) = 7.627982 MRT(0-inf) = 8.65709 ---------------------------- Test --------------------------------------------------- << NCA Outputs:- Subj.# 1 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 1 0.00 0.0 0.000 0.000 2 1 0.25 84.5 10.562 2.641 3 1 0.50 192.0 45.125 17.281 4 1 0.75 629.0 147.750 88.250 5 1 1.00 873.0 335.500 256.344 6 1 1.50 1246.0 865.250 941.844 7 1 2.00 1633.0 1585.000 2225.594 8 1 3.00 1375.0 3089.000 5921.094 9 1 4.00 1006.0 4279.500 9995.594 10 1 8.00 616.0 7523.500 27899.594 11 1 12.00 379.0 9513.500 46851.594 12 1 24.00 84.4 12293.900 86293.194 <> -------------------------------------------------- subj seq prd drug time conc code 9 1 2 1 2 4 1006.0 1 10 1 2 1 2 8 616.0 1 11 1 2 1 2 12 379.0 1 12 1 2 1 2 24 84.4 1 <> ---------------------------- R sq. = 0.9999566 Adj. R sq. (ARS) = 0.999935 AIC = -36.77908 lambda_z = 0.1240003 Cmax = 1633 Tmax = 2 Cl/F = 6.16592 Vd/F = 49.72502 T1/2(z) = 5.589881 AUC(0-t) = 12293.9 AUC(0-inf) = 12974.54 AUMC(0-t) = 86293.2 AUMC(0-inf) = 108117.7 MRT(0-t) = 7.019188 MRT(0-inf) = 8.333062 ---------------------------- << NCA Outputs:- Subj.# 1 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 1 0.00 0 0.000 0.000 2 1 0.25 75 9.375 2.344 3 1 0.50 180 41.250 15.938 4 1 0.75 621 141.375 85.406 5 1 1.00 870 327.750 252.375 6 1 1.50 1253 858.500 939.750 7 1 2.00 1541 1557.000 2180.125 8 1 3.00 1375 3015.000 5783.625 9 1 4.00 999 4202.000 9844.125 10 1 8.00 400 7000.000 24236.125 11 1 12.00 360 8520.000 39276.125 12 1 24.00 82 11172.000 77004.125 <> -------------------------------------------------- subj seq prd drug time conc code 20 1 2 4 2 3 1375 4 21 1 2 4 2 4 999 4 22 1 2 4 2 8 400 4 23 1 2 4 2 12 360 4 24 1 2 4 2 24 82 4 <> ---------------------------- R sq. = 0.9590945 Adj. R sq. (ARS) = 0.9454594 AIC = -12.14243 lambda_z = 0.1268147 Cmax = 1541 Tmax = 2 Cl/F = 6.768984 Vd/F = 53.37695 T1/2(z) = 5.465826 AUC(0-t) = 11172 AUC(0-inf) = 11818.61 AUMC(0-t) = 77004.12 AUMC(0-inf) = 97621.7 MRT(0-t) = 6.8926 MRT(0-inf) = 8.259997 ---------------------------- << NCA Outputs:- Subj.# 2 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 2 0.00 0.0 0.000 0.000 2 2 0.25 30.1 3.763 0.941 3 2 0.50 211.0 33.900 15.069 4 2 0.75 1221.0 212.900 142.725 5 2 1.00 1485.0 551.150 442.819 6 2 1.50 1837.0 1381.650 1502.944 7 2 2.00 1615.0 2244.650 2999.319 8 2 3.00 1621.0 3862.650 7045.819 9 2 4.00 1411.0 5378.650 12299.319 10 2 8.00 763.0 9726.650 35795.319 11 2 12.00 424.0 12100.650 58179.319 12 2 24.00 109.0 15298.650 104403.319 <> -------------------------------------------------- subj seq prd drug time conc code 31 2 1 2 2 2 1615 6 32 2 1 2 2 3 1621 6 33 2 1 2 2 4 1411 6 34 2 1 2 2 8 763 6 35 2 1 2 2 12 424 6 36 2 1 2 2 24 109 6 <> ---------------------------- R sq. = 0.9944254 Adj. R sq. (ARS) = 0.9930318 AIC = -27.53936 lambda_z = 0.1272049 Cmax = 1837 Tmax = 1.5 Cl/F = 4.951863 Vd/F = 38.92825 T1/2(z) = 5.449061 AUC(0-t) = 15298.65 AUC(0-inf) = 16155.54 AUMC(0-t) = 104403.3 AUMC(0-inf) = 131704.8 MRT(0-t) = 6.824348 MRT(0-inf) = 8.152304 ---------------------------- << NCA Outputs:- Subj.# 2 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 2 0.00 0 0.000 0.000 2 2 0.25 30 3.750 0.938 3 2 0.50 219 34.875 15.562 4 2 0.75 1323 227.625 153.281 5 2 1.00 1495 579.875 464.188 6 2 1.50 1847 1415.375 1530.562 7 2 2.00 1625 2283.375 3035.688 8 2 3.00 1531 3861.375 6957.188 9 2 4.00 1421 5337.375 12095.688 10 2 8.00 763 9705.375 35671.688 11 2 12.00 434 12099.375 58295.688 12 2 24.00 119 15417.375 106679.688 <> -------------------------------------------------- subj seq prd drug time conc code 43 2 1 3 2 2 1625 7 44 2 1 3 2 3 1531 7 45 2 1 3 2 4 1421 7 46 2 1 3 2 8 763 7 47 2 1 3 2 12 434 7 48 2 1 3 2 24 119 7 <> ---------------------------- R sq. = 0.9943983 Adj. R sq. (ARS) = 0.9929979 AIC = -27.97358 lambda_z = 0.1223852 Cmax = 1847 Tmax = 1.5 Cl/F = 4.88111 Vd/F = 39.88316 T1/2(z) = 5.663651 AUC(0-t) = 15417.38 AUC(0-inf) = 16389.71 AUMC(0-t) = 106679.7 AUMC(0-inf) = 137960.7 MRT(0-t) = 6.919446 MRT(0-inf) = 8.41752 ---------------------------- << NCA Outputs:- Subj.# 3 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 3 0.00 0.0 0.000 0.000 2 3 0.25 32.8 4.100 1.025 3 3 0.50 181.0 30.825 13.363 4 3 0.75 271.0 87.325 50.081 5 3 1.00 402.0 171.450 125.737 6 3 1.50 783.0 467.700 519.862 7 3 2.00 2073.0 1181.700 1849.987 8 3 3.00 1842.0 3139.200 6685.988 9 3 4.00 1610.0 4865.200 12668.987 10 3 8.00 883.0 9851.200 39676.988 11 3 12.00 389.0 12395.200 63140.988 12 3 24.00 75.8 15184.000 102064.188 <> -------------------------------------------------- subj seq prd drug time conc code 56 3 2 1 2 3 1842.0 9 57 3 2 1 2 4 1610.0 9 58 3 2 1 2 8 883.0 9 59 3 2 1 2 12 389.0 9 60 3 2 1 2 24 75.8 9 <> ---------------------------- R sq. = 0.995476 Adj. R sq. (ARS) = 0.993968 AIC = -21.41795 lambda_z = 0.1536559 Cmax = 2073 Tmax = 2 Cl/F = 5.102916 Vd/F = 33.21003 T1/2(z) = 4.511035 AUC(0-t) = 15184 AUC(0-inf) = 15677.31 AUMC(0-t) = 102064.2 AUMC(0-inf) = 117114.1 MRT(0-t) = 6.721825 MRT(0-inf) = 7.470294 ---------------------------- << NCA Outputs:- Subj.# 3 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 3 0.00 0 0.000 0.000 2 3 0.25 32 4.000 1.000 3 3 0.50 171 29.375 12.688 4 3 0.75 281 85.875 49.719 5 3 1.00 412 172.500 127.562 6 3 1.50 793 473.750 527.938 7 3 2.00 2183 1217.750 1916.812 8 3 3.00 1852 3235.250 6877.812 9 3 4.00 1620 4971.250 12895.812 10 3 8.00 840 9891.250 39295.812 11 3 12.00 390 12351.250 62095.812 12 3 24.00 76 15147.250 101119.812 <> -------------------------------------------------- subj seq prd drug time conc code 68 3 2 4 2 3 1852 12 69 3 2 4 2 4 1620 12 70 3 2 4 2 8 840 12 71 3 2 4 2 12 390 12 72 3 2 4 2 24 76 12 <> ---------------------------- R sq. = 0.9958295 Adj. R sq. (ARS) = 0.9944393 AIC = -21.84318 lambda_z = 0.1534016 Cmax = 2183 Tmax = 2 Cl/F = 5.114213 Vd/F = 33.33872 T1/2(z) = 4.518514 AUC(0-t) = 15147.25 AUC(0-inf) = 15642.68 AUMC(0-t) = 101119.8 AUMC(0-inf) = 116239.8 MRT(0-t) = 6.675787 MRT(0-inf) = 7.430939 ---------------------------- << NCA Outputs:- Subj.# 4 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 4 0.00 0.0 0.000 0.000 2 4 0.25 30.8 3.850 0.963 3 4 0.50 198.0 32.450 14.300 4 4 0.75 395.0 106.575 63.706 5 4 1.00 906.0 269.200 213.988 6 4 1.50 1413.0 848.950 970.362 7 4 2.00 1629.0 1609.450 2314.738 8 4 3.00 1501.0 3174.450 6195.238 9 4 4.00 1383.0 4616.450 11212.737 10 4 8.00 713.0 8808.450 33684.738 11 4 12.00 403.0 11040.450 54764.738 12 4 24.00 87.2 13981.650 96337.538 <> -------------------------------------------------- subj seq prd drug time conc code 80 4 1 2 2 3 1501.0 14 81 4 1 2 2 4 1383.0 14 82 4 1 2 2 8 713.0 14 83 4 1 2 2 12 403.0 14 84 4 1 2 2 24 87.2 14 <> ---------------------------- R sq. = 0.9974802 Adj. R sq. (ARS) = 0.9966402 AIC = -25.52007 lambda_z = 0.1367452 Cmax = 1629 Tmax = 2 Cl/F = 5.472206 Vd/F = 40.01755 T1/2(z) = 5.068897 AUC(0-t) = 13981.65 AUC(0-inf) = 14619.33 AUMC(0-t) = 96337.54 AUMC(0-inf) = 116305.2 MRT(0-t) = 6.890284 MRT(0-inf) = 7.955576 ---------------------------- << NCA Outputs:- Subj.# 4 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 4 0.00 0.0 0.000 0.000 2 4 0.25 29.8 3.725 0.931 3 4 0.50 120.0 22.450 9.363 4 4 0.75 385.0 85.575 52.956 5 4 1.00 850.0 239.950 195.300 6 4 1.50 1403.0 803.200 933.925 7 4 2.00 1619.0 1558.700 2269.550 8 4 3.00 1590.0 3163.200 6273.550 9 4 4.00 1373.0 4644.700 11404.550 10 4 8.00 703.0 8796.700 33636.550 11 4 12.00 500.0 11202.700 56884.550 12 4 24.00 85.2 14713.900 105153.350 <> -------------------------------------------------- subj seq prd drug time conc code 92 4 1 3 2 3 1590.0 15 93 4 1 3 2 4 1373.0 15 94 4 1 3 2 8 703.0 15 95 4 1 3 2 12 500.0 15 96 4 1 3 2 24 85.2 15 <> ---------------------------- R sq. = 0.9958546 Adj. R sq. (ARS) = 0.9944728 AIC = -22.95455 lambda_z = 0.1376824 Cmax = 1619 Tmax = 2 Cl/F = 5.217601 Vd/F = 37.89593 T1/2(z) = 5.034394 AUC(0-t) = 14713.9 AUC(0-inf) = 15332.72 AUMC(0-t) = 105153.4 AUMC(0-inf) = 124499.4 MRT(0-t) = 7.146532 MRT(0-inf) = 8.119856 ---------------------------- << NCA Outputs:- Subj.# 5 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 5 0.00 0.0 0.000 0.000 2 5 0.25 25.8 3.225 0.806 3 5 0.50 151.0 25.325 11.050 4 5 0.75 523.0 109.575 69.519 5 5 1.00 1031.0 303.825 247.425 6 5 1.50 1294.0 885.075 990.425 7 5 2.00 1385.0 1554.825 2168.175 8 5 3.00 1291.0 2892.825 5489.675 9 5 4.00 1143.0 4109.825 9712.175 10 5 8.00 571.0 7537.825 27992.175 11 5 12.00 334.0 9347.825 45144.175 12 5 24.00 83.3 11851.625 81187.375 <> -------------------------------------------------- subj seq prd drug time conc code 104 5 2 1 2 3 1291.0 17 105 5 2 1 2 4 1143.0 17 106 5 2 1 2 8 571.0 17 107 5 2 1 2 12 334.0 17 108 5 2 1 2 24 83.3 17 <> ---------------------------- R sq. = 0.9927064 Adj. R sq. (ARS) = 0.9902752 AIC = -20.64487 lambda_z = 0.1305610 Cmax = 1385 Tmax = 2 Cl/F = 6.405308 Vd/F = 49.0599 T1/2(z) = 5.308993 AUC(0-t) = 11851.62 AUC(0-inf) = 12489.64 AUMC(0-t) = 81187.38 AUMC(0-inf) = 101386.5 MRT(0-t) = 6.850316 MRT(0-inf) = 8.117647 ---------------------------- << NCA Outputs:- Subj.# 5 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 5 0.00 0.0 0.000 0.000 2 5 0.25 25.0 3.125 0.781 3 5 0.50 150.0 25.000 10.938 4 5 0.75 513.0 107.875 68.406 5 5 1.00 1021.0 299.625 244.125 6 5 1.50 1280.0 874.875 979.375 7 5 2.00 1386.0 1541.375 2152.375 8 5 3.00 1281.0 2874.875 5459.875 9 5 4.00 1133.0 4081.875 9647.375 10 5 8.00 561.0 7469.875 27687.375 11 5 12.00 324.0 9239.875 44439.375 12 5 24.00 81.3 11671.675 79474.575 <> -------------------------------------------------- subj seq prd drug time conc code 116 5 2 4 2 3 1281.0 20 117 5 2 4 2 4 1133.0 20 118 5 2 4 2 8 561.0 20 119 5 2 4 2 12 324.0 20 120 5 2 4 2 24 81.3 20 <> ---------------------------- R sq. = 0.9918595 Adj. R sq. (ARS) = 0.989146 AIC = -20.02767 lambda_z = 0.1313946 Cmax = 1386 Tmax = 2 Cl/F = 6.509134 Vd/F = 49.53883 T1/2(z) = 5.27531 AUC(0-t) = 11671.67 AUC(0-inf) = 12290.42 AUMC(0-t) = 79474.57 AUMC(0-inf) = 99033.58 MRT(0-t) = 6.809183 MRT(0-inf) = 8.057785 ---------------------------- << NCA Outputs:- Subj.# 6 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 6 0.00 0.0 0.000 0.000 2 6 0.50 140.0 35.000 17.500 3 6 0.75 643.0 132.875 86.531 4 6 1.00 909.0 326.875 260.438 5 6 1.50 1073.0 822.375 890.062 6 6 2.00 1252.0 1403.625 1918.438 7 6 3.00 1522.0 2790.625 5453.438 8 6 4.00 1375.0 4239.125 10486.438 9 6 8.00 795.0 8579.125 34206.438 10 6 12.00 403.0 10975.125 56598.438 11 6 24.00 74.1 13837.725 96284.837 <> -------------------------------------------------- subj seq prd drug time conc code 128 6 1 2 2 4 1375.0 22 129 6 1 2 2 8 795.0 22 130 6 1 2 2 12 403.0 22 131 6 1 2 2 24 74.1 22 <> ---------------------------- R sq. = 0.9990527 Adj. R sq. (ARS) = 0.998579 AIC = -23.09787 lambda_z = 0.1466877 Cmax = 1522 Tmax = 3 Cl/F = 5.57768 Vd/F = 38.02418 T1/2(z) = 4.725325 AUC(0-t) = 13837.73 AUC(0-inf) = 14342.88 AUMC(0-t) = 96284.84 AUMC(0-inf) = 111852.3 MRT(0-t) = 6.958141 MRT(0-inf) = 7.798454 ---------------------------- << NCA Outputs:- Subj.# 6 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 6 0.00 0.0 0.000 0.000 2 6 0.50 130.0 32.500 16.250 3 6 0.75 633.0 127.875 83.719 4 6 1.00 919.0 321.875 257.938 5 6 1.50 1083.0 822.375 893.812 6 6 2.00 1242.0 1403.625 1920.938 7 6 3.00 1512.0 2780.625 5430.938 8 6 4.00 1385.0 4229.125 10468.938 9 6 8.00 785.0 8569.125 34108.938 10 6 12.00 413.0 10965.125 56580.938 11 6 24.00 71.1 13869.725 96555.337 <> -------------------------------------------------- subj seq prd drug time conc code 139 6 1 3 2 4 1385.0 23 140 6 1 3 2 8 785.0 23 141 6 1 3 2 12 413.0 23 142 6 1 3 2 24 71.1 23 <> ---------------------------- R sq. = 0.9997737 Adj. R sq. (ARS) = 0.9996606 AIC = -28.70688 lambda_z = 0.1489345 Cmax = 1512 Tmax = 3 Cl/F = 5.576034 Vd/F = 37.4395 T1/2(z) = 4.65404 AUC(0-t) = 13869.73 AUC(0-inf) = 14347.12 AUMC(0-t) = 96555.34 AUMC(0-inf) = 111218.1 MRT(0-t) = 6.96159 MRT(0-inf) = 7.751948 ---------------------------- << NCA Outputs:- Subj.# 7 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 7 0.00 0.0 0.000 0.000 2 7 0.50 151.0 37.750 18.875 3 7 0.75 510.0 120.375 76.125 4 7 1.00 1023.0 312.000 251.812 5 7 1.50 1477.0 937.000 1061.438 6 7 2.00 1643.0 1717.000 2436.812 7 7 3.00 1524.0 3300.500 6365.812 8 7 4.00 1126.0 4625.500 10903.812 9 7 8.00 577.0 8031.500 29143.812 10 7 12.00 339.0 9863.500 46511.812 11 7 24.00 77.3 12361.300 82051.012 <> -------------------------------------------------- subj seq prd drug time conc code 151 7 2 1 2 8 577.0 25 152 7 2 1 2 12 339.0 25 153 7 2 1 2 24 77.3 25 <> ---------------------------- R sq. = 0.9997564 Adj. R sq. (ARS) = 0.9995128 AIC = -21.93233 lambda_z = 0.1250707 Cmax = 1643 Tmax = 2 Cl/F = 6.163637 Vd/F = 49.28122 T1/2(z) = 5.542042 AUC(0-t) = 12361.3 AUC(0-inf) = 12979.35 AUMC(0-t) = 82051.01 AUMC(0-inf) = 101825.8 MRT(0-t) = 6.637733 MRT(0-inf) = 7.845218 ---------------------------- << NCA Outputs:- Subj.# 7 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 7 0.00 0.0 0.000 0.000 2 7 0.50 161.0 40.250 20.125 3 7 0.75 520.0 125.375 78.938 4 7 1.00 1013.0 317.000 254.312 5 7 1.50 1467.0 937.000 1057.688 6 7 2.00 1653.0 1717.000 2434.312 7 7 3.00 1534.0 3310.500 6388.312 8 7 4.00 1136.0 4645.500 10961.312 9 7 8.00 900.0 8717.500 34449.312 10 7 12.00 359.0 11235.500 57465.312 11 7 24.00 70.3 13811.300 93436.512 <> -------------------------------------------------- subj seq prd drug time conc code 160 7 2 4 2 3 1534.0 28 161 7 2 4 2 4 1136.0 28 162 7 2 4 2 8 900.0 28 163 7 2 4 2 12 359.0 28 164 7 2 4 2 24 70.3 28 <> ---------------------------- R sq. = 0.9872397 Adj. R sq. (ARS) = 0.9829863 AIC = -16.71298 lambda_z = 0.1458527 Cmax = 1653 Tmax = 2 Cl/F = 5.597031 Vd/F = 38.37454 T1/2(z) = 4.752377 AUC(0-t) = 13811.3 AUC(0-inf) = 14293.29 AUMC(0-t) = 93436.51 AUMC(0-inf) = 108309 MRT(0-t) = 6.765222 MRT(0-inf) = 7.57761 ---------------------------- << NCA Outputs:- Subj.# 8 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 8 0.00 0.0 0.000 0.000 2 8 0.25 55.8 6.975 1.744 3 8 0.50 132.0 30.450 11.738 4 8 0.75 401.0 97.075 57.581 5 8 1.00 762.0 242.450 190.425 6 8 1.50 1118.0 712.450 800.175 7 8 2.00 1598.0 1391.450 2018.425 8 8 3.00 1615.0 2997.950 6038.925 9 8 4.00 1480.0 4545.450 11421.425 10 8 8.00 854.0 9213.450 36925.425 11 8 12.00 386.0 11693.450 59853.425 12 8 24.00 56.2 14346.650 95738.225 <> -------------------------------------------------- subj seq prd drug time conc code 173 8 1 2 2 4 1480.0 30 174 8 1 2 2 8 854.0 30 175 8 1 2 2 12 386.0 30 176 8 1 2 2 24 56.2 30 <> ---------------------------- R sq. = 0.9983398 Adj. R sq. (ARS) = 0.9975097 AIC = -19.89006 lambda_z = 0.1654067 Cmax = 1615 Tmax = 3 Cl/F = 5.44721 Vd/F = 32.93222 T1/2(z) = 4.190563 AUC(0-t) = 14346.65 AUC(0-inf) = 14686.42 AUMC(0-t) = 95738.23 AUMC(0-inf) = 105946.8 MRT(0-t) = 6.673211 MRT(0-inf) = 7.213931 ---------------------------- << NCA Outputs:- Subj.# 8 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 8 0.00 0.0 0.000 0.000 2 8 0.25 59.8 7.475 1.869 3 8 0.50 142.0 32.700 12.613 4 8 0.75 411.0 101.825 60.019 5 8 1.00 810.0 254.450 199.800 6 8 1.50 1128.0 738.950 825.300 7 8 2.00 1588.0 1417.950 2042.300 8 8 3.00 1725.0 3074.450 6217.800 9 8 4.00 1470.0 4671.950 11745.300 10 8 8.00 824.0 9259.950 36689.300 11 8 12.00 200.0 11307.950 54673.300 12 8 24.00 53.2 12827.150 76734.100 <> -------------------------------------------------- subj seq prd drug time conc code 185 8 1 3 2 4 1470.0 31 186 8 1 3 2 8 824.0 31 187 8 1 3 2 12 200.0 31 188 8 1 3 2 24 53.2 31 <> ---------------------------- R sq. = 0.9448015 Adj. R sq. (ARS) = 0.9172022 AIC = -5.554601 lambda_z = 0.1674648 Cmax = 1725 Tmax = 3 Cl/F = 6.086044 Vd/F = 36.34222 T1/2(z) = 4.139061 AUC(0-t) = 12827.15 AUC(0-inf) = 13144.83 AUMC(0-t) = 76734.1 AUMC(0-inf) = 86255.37 MRT(0-t) = 5.982163 MRT(0-inf) = 6.561925 ---------------------------- << NCA Outputs:- Subj.# 9 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 9 0.00 0.0 0.000 0.000 2 9 0.50 57.0 14.250 7.125 3 9 0.75 544.0 89.375 61.688 4 9 1.00 975.0 279.250 234.562 5 9 1.50 1217.0 827.250 934.688 6 9 2.00 1126.0 1413.000 1954.062 7 9 3.00 1759.0 2855.500 5718.562 8 9 4.00 1564.0 4517.000 11485.062 9 9 8.00 867.0 9379.000 37869.062 10 9 12.00 510.0 12133.000 63981.062 11 9 24.00 101.9 15804.400 115374.663 <> -------------------------------------------------- subj seq prd drug time conc code 197 9 2 1 2 8 867.0 33 198 9 2 1 2 12 510.0 33 199 9 2 1 2 24 101.9 33 <> ---------------------------- R sq. = 0.9999947 Adj. R sq. (ARS) = 0.9999894 AIC = -32.99901 lambda_z = 0.1339045 Cmax = 1759 Tmax = 3 Cl/F = 4.829346 Vd/F = 36.06559 T1/2(z) = 5.176428 AUC(0-t) = 15804.4 AUC(0-inf) = 16565.39 AUMC(0-t) = 115374.7 AUMC(0-inf) = 139321.5 MRT(0-t) = 7.300161 MRT(0-inf) = 8.410396 ---------------------------- << NCA Outputs:- Subj.# 9 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 9 0.00 0.0 0.000 0.000 2 9 0.50 58.0 14.500 7.250 3 9 0.75 534.0 88.500 60.938 4 9 1.00 985.0 278.375 234.125 5 9 1.50 1227.0 831.375 940.500 6 9 2.00 1136.0 1422.125 1968.625 7 9 3.00 1769.0 2874.625 5758.125 8 9 4.00 1574.0 4546.125 11559.625 9 9 8.00 877.0 9448.125 38183.625 10 9 12.00 300.0 11802.125 59415.625 11 9 24.00 111.9 14273.525 97129.225 <> -------------------------------------------------- subj seq prd drug time conc code 207 9 2 4 2 4 1574.0 36 208 9 2 4 2 8 877.0 36 209 9 2 4 2 12 300.0 36 210 9 2 4 2 24 111.9 36 <> ---------------------------- R sq. = 0.9378705 Adj. R sq. (ARS) = 0.9068057 AIC = -7.005243 lambda_z = 0.1311864 Cmax = 1769 Tmax = 3 Cl/F = 5.288728 Vd/F = 40.31459 T1/2(z) = 5.28368 AUC(0-t) = 14273.52 AUC(0-inf) = 15126.51 AUMC(0-t) = 97129.23 AUMC(0-inf) = 124102.9 MRT(0-t) = 6.804852 MRT(0-inf) = 8.204334 ---------------------------- << NCA Outputs:- Subj.# 10 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 10 0.00 0 0.000 0.000 2 10 0.50 93 23.250 11.625 3 10 0.75 769 131.000 89.531 4 10 1.00 1024 355.125 289.625 5 10 1.50 1135 894.875 971.250 6 10 2.00 1483 1549.375 2138.375 7 10 3.00 1260 2920.875 5511.375 8 10 4.00 1013 4057.375 9427.375 9 10 8.00 523 7129.375 25899.375 10 10 12.00 373 8921.375 43219.375 11 10 24.00 92 11711.375 83323.375 <> -------------------------------------------------- subj seq prd drug time conc code 217 10 1 2 2 3 1260 38 218 10 1 2 2 4 1013 38 219 10 1 2 2 8 523 38 220 10 1 2 2 12 373 38 221 10 1 2 2 24 92 38 <> ---------------------------- R sq. = 0.9905328 Adj. R sq. (ARS) = 0.9873771 AIC = -20.06887 lambda_z = 0.1212589 Cmax = 1483 Tmax = 2 Cl/F = 6.415355 Vd/F = 52.90627 T1/2(z) = 5.71626 AUC(0-t) = 11711.38 AUC(0-inf) = 12470.08 AUMC(0-t) = 83323.38 AUMC(0-inf) = 107789.3 MRT(0-t) = 7.114739 MRT(0-inf) = 8.64383 ---------------------------- << NCA Outputs:- Subj.# 10 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 10 0.00 0 0.000 0.000 2 10 0.50 99 24.750 12.375 3 10 0.75 779 134.500 91.594 4 10 1.00 1034 361.125 293.875 5 10 1.50 1145 905.875 981.750 6 10 2.00 1693 1615.375 2257.625 7 10 3.00 1270 3096.875 5855.625 8 10 4.00 1003 4233.375 9766.625 9 10 8.00 513 7265.375 25998.625 10 10 12.00 383 9057.375 43398.625 11 10 24.00 90 11895.375 83934.625 <> -------------------------------------------------- subj seq prd drug time conc code 228 10 1 3 2 3 1270 39 229 10 1 3 2 4 1003 39 230 10 1 3 2 8 513 39 231 10 1 3 2 12 383 39 232 10 1 3 2 24 90 39 <> ---------------------------- R sq. = 0.9891394 Adj. R sq. (ARS) = 0.9855192 AIC = -19.31586 lambda_z = 0.1219813 Cmax = 1693 Tmax = 2 Cl/F = 6.332524 Vd/F = 51.91391 T1/2(z) = 5.682408 AUC(0-t) = 11895.38 AUC(0-inf) = 12633.19 AUMC(0-t) = 83934.62 AUMC(0-inf) = 107690.9 MRT(0-t) = 7.056072 MRT(0-inf) = 8.524439 ---------------------------- << NCA Outputs:- Subj.# 11 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 11 0.00 0.0 0.000 0.000 2 11 0.25 42.8 5.350 1.337 3 11 0.50 136.0 27.700 11.175 4 11 0.75 442.0 99.950 61.112 5 11 1.00 751.0 249.075 196.425 6 11 1.50 1227.0 743.575 844.300 7 11 2.00 1682.0 1470.825 2145.425 8 11 3.00 1517.0 3070.325 6102.925 9 11 4.00 1379.0 4518.325 11136.425 10 11 8.00 791.0 8858.325 34824.425 11 11 12.00 548.0 11536.325 60632.425 12 11 24.00 91.1 15370.925 113206.825 <> -------------------------------------------------- subj seq prd drug time conc code 240 11 2 1 2 3 1517.0 41 241 11 2 1 2 4 1379.0 41 242 11 2 1 2 8 791.0 41 243 11 2 1 2 12 548.0 41 244 11 2 1 2 24 91.1 41 <> ---------------------------- R sq. = 0.9951984 Adj. R sq. (ARS) = 0.993598 AIC = -22.5077 lambda_z = 0.1337319 Cmax = 1682 Tmax = 2 Cl/F = 4.98376 Vd/F = 37.26679 T1/2(z) = 5.18311 AUC(0-t) = 15370.93 AUC(0-inf) = 16052.14 AUMC(0-t) = 113206.8 AUMC(0-inf) = 134649.8 MRT(0-t) = 7.364998 MRT(0-inf) = 8.38828 ---------------------------- << NCA Outputs:- Subj.# 11 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 11 0.00 0.0 0.000 0.000 2 11 0.25 41.8 5.225 1.306 3 11 0.50 146.0 28.700 11.738 4 11 0.75 462.0 104.700 64.175 5 11 1.00 741.0 255.075 200.113 6 11 1.50 1287.0 762.075 867.987 7 11 2.00 1692.0 1506.825 2196.613 8 11 3.00 1507.0 3106.325 6149.113 9 11 4.00 1169.0 4444.325 10747.612 10 11 8.00 781.0 8344.325 32595.612 11 11 12.00 338.0 10582.325 53203.613 12 11 24.00 90.1 13150.925 90514.012 <> -------------------------------------------------- subj seq prd drug time conc code 252 11 2 4 2 3 1507.0 44 253 11 2 4 2 4 1169.0 44 254 11 2 4 2 8 781.0 44 255 11 2 4 2 12 338.0 44 256 11 2 4 2 24 90.1 44 <> ---------------------------- R sq. = 0.9873224 Adj. R sq. (ARS) = 0.9830966 AIC = -17.63367 lambda_z = 0.1334626 Cmax = 1692 Tmax = 2 Cl/F = 5.786191 Vd/F = 43.3544 T1/2(z) = 5.193569 AUC(0-t) = 13150.93 AUC(0-inf) = 13826.02 AUMC(0-t) = 90514.01 AUMC(0-inf) = 111774.6 MRT(0-t) = 6.882711 MRT(0-inf) = 8.084367 ---------------------------- << NCA Outputs:- Subj.# 12 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 12 0.00 0 0.000 0.000 2 12 0.50 114 28.500 14.250 3 12 0.75 419 95.125 60.656 4 12 1.00 650 228.750 181.188 5 12 1.50 1023 647.000 727.312 6 12 2.00 1247 1214.500 1734.438 7 12 3.00 1129 2402.500 4674.938 8 12 4.00 987 3460.500 8342.438 9 12 8.00 564 6562.500 25262.438 10 12 12.00 316 8322.500 41870.438 11 12 24.00 65 10608.500 73982.438 <> -------------------------------------------------- subj seq prd drug time conc code 263 12 1 2 2 3 1129 46 264 12 1 2 2 4 987 46 265 12 1 2 2 8 564 46 266 12 1 2 2 12 316 46 267 12 1 2 2 24 65 46 <> ---------------------------- R sq. = 0.9996462 Adj. R sq. (ARS) = 0.9995282 AIC = -35.38847 lambda_z = 0.1361725 Cmax = 1247 Tmax = 2 Cl/F = 7.216416 Vd/F = 52.99466 T1/2(z) = 5.090213 AUC(0-t) = 10608.5 AUC(0-inf) = 11085.84 AUMC(0-t) = 73982.44 AUMC(0-inf) = 88943.87 MRT(0-t) = 6.973883 MRT(0-inf) = 8.023199 ---------------------------- << NCA Outputs:- Subj.# 12 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 12 0.00 0 0.000 0.000 2 12 0.50 124 31.000 15.500 3 12 0.75 429 100.125 63.469 4 12 1.00 660 236.250 186.188 5 12 1.50 1013 654.500 731.062 6 12 2.00 1657 1322.000 1939.438 7 12 3.00 1239 2770.000 5454.938 8 12 4.00 777 3778.000 8867.438 9 12 8.00 574 6480.000 24267.438 10 12 12.00 226 8080.000 38875.438 11 12 24.00 60 9796.000 63787.438 <> -------------------------------------------------- subj seq prd drug time conc code 274 12 1 3 2 3 1239 47 275 12 1 3 2 4 777 47 276 12 1 3 2 8 574 47 277 12 1 3 2 12 226 47 278 12 1 3 2 24 60 47 <> ---------------------------- R sq. = 0.9751865 Adj. R sq. (ARS) = 0.9669153 AIC = -13.77861 lambda_z = 0.1394025 Cmax = 1657 Tmax = 2 Cl/F = 7.822883 Vd/F = 56.11726 T1/2(z) = 4.972274 AUC(0-t) = 9796 AUC(0-inf) = 10226.41 AUMC(0-t) = 63787.44 AUMC(0-inf) = 77204.77 MRT(0-t) = 6.51158 MRT(0-inf) = 7.549548 ---------------------------- << NCA Outputs:- Subj.# 13 , Seq 2 , Prd 1 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 13 0.00 0.0 0.000 0.000 2 13 0.50 50.0 12.500 6.250 3 13 0.75 216.0 45.750 29.625 4 13 1.00 762.0 168.000 145.125 5 13 1.50 1144.0 644.500 764.625 6 13 2.00 1238.0 1240.000 1812.625 7 13 3.00 1605.0 2661.500 5458.125 8 13 4.00 1472.0 4200.000 10809.625 9 13 8.00 880.0 8904.000 36665.625 10 13 12.00 511.0 11686.000 63009.625 11 13 24.00 112.6 15427.600 116016.025 <> -------------------------------------------------- subj seq prd drug time conc code 286 13 2 1 2 4 1472.0 49 287 13 2 1 2 8 880.0 49 288 13 2 1 2 12 511.0 49 289 13 2 1 2 24 112.6 49 <> ---------------------------- R sq. = 0.9998215 Adj. R sq. (ARS) = 0.9997322 AIC = -30.83443 lambda_z = 0.1285206 Cmax = 1605 Tmax = 3 Cl/F = 4.906854 Vd/F = 38.17953 T1/2(z) = 5.393279 AUC(0-t) = 15427.6 AUC(0-inf) = 16303.72 AUMC(0-t) = 116016.0 AUMC(0-inf) = 143860 MRT(0-t) = 7.52003 MRT(0-inf) = 8.823751 ---------------------------- << NCA Outputs:- Subj.# 13 , Seq 2 , Prd 4 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 13 0.00 0.0 0.000 0.000 2 13 0.50 55.0 13.750 6.875 3 13 0.75 226.0 48.875 31.500 4 13 1.00 572.0 148.625 124.188 5 13 1.50 1154.0 580.125 699.938 6 13 2.00 1348.0 1205.625 1806.688 7 13 3.00 1615.0 2687.125 5577.188 8 13 4.00 1482.0 4235.625 10963.688 9 13 8.00 670.0 8539.625 33539.688 10 13 12.00 321.0 10521.625 51963.688 11 13 24.00 122.6 13183.225 92730.087 <> -------------------------------------------------- subj seq prd drug time conc code 297 13 2 4 2 4 1482.0 52 298 13 2 4 2 8 670.0 52 299 13 2 4 2 12 321.0 52 300 13 2 4 2 24 122.6 52 <> ---------------------------- R sq. = 0.9428269 Adj. R sq. (ARS) = 0.9142403 AIC = -8.116314 lambda_z = 0.1193356 Cmax = 1615 Tmax = 3 Cl/F = 5.629608 Vd/F = 47.1746 T1/2(z) = 5.808387 AUC(0-t) = 13183.23 AUC(0-inf) = 14210.58 AUMC(0-t) = 92730.09 AUMC(0-inf) = 125995.6 MRT(0-t) = 7.033946 MRT(0-inf) = 8.866321 ---------------------------- << NCA Outputs:- Subj.# 14 , Seq 1 , Prd 2 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 14 0.00 0 0.000 0.000 2 14 0.50 152 38.000 19.000 3 14 0.75 600 132.000 84.750 4 14 1.00 874 316.250 250.250 5 14 1.50 1121 815.000 889.125 6 14 2.00 1678 1514.750 2148.500 7 14 3.00 1718 3212.750 6403.500 8 14 4.00 1590 4866.750 12160.500 9 14 8.00 984 10014.750 40624.500 10 14 12.00 627 13236.750 71416.500 11 14 24.00 134 17802.750 135856.500 <> -------------------------------------------------- subj seq prd drug time conc code 308 14 1 2 2 4 1590 54 309 14 1 2 2 8 984 54 310 14 1 2 2 12 627 54 311 14 1 2 2 24 134 54 <> ---------------------------- R sq. = 0.9993276 Adj. R sq. (ARS) = 0.9989914 AIC = -25.81780 lambda_z = 0.1239479 Cmax = 1718 Tmax = 3 Cl/F = 4.236424 Vd/F = 34.17906 T1/2(z) = 5.592244 AUC(0-t) = 17802.75 AUC(0-inf) = 18883.85 AUMC(0-t) = 135856.5 AUMC(0-inf) = 170525.1 MRT(0-t) = 7.631209 MRT(0-inf) = 9.030208 ---------------------------- << NCA Outputs:- Subj.# 14 , Seq 1 , Prd 3 (Test)>> -------------------------------------------------------------------------- subj time conc AUC(0~t) AUMC(0~t) 1 14 0.00 0 0.000 0.000 2 14 0.50 142 35.500 17.750 3 14 0.75 610 129.500 83.812 4 14 1.00 984 328.750 264.000 5 14 1.50 1131 857.500 934.125 6 14 2.00 1688 1562.250 2202.250 7 14 3.00 1828 3320.250 6632.250 8 14 4.00 1580 5024.250 12534.250 9 14 8.00 864 9912.250 38998.250 10 14 12.00 617 12874.250 67630.250 11 14 24.00 234 17980.250 145750.250 <> -------------------------------------------------- subj seq prd drug time conc code 320 14 1 3 2 8 864 55 321 14 1 3 2 12 617 55 322 14 1 3 2 24 234 55 <> ---------------------------- R sq. = 0.9999312 Adj. R sq. (ARS) = 0.9998624 AIC = -28.29947 lambda_z = 0.08144571 Cmax = 1828 Tmax = 3 Cl/F = 3.836318 Vd/F = 47.10276 T1/2(z) = 8.510542 AUC(0-t) = 17980.25 AUC(0-inf) = 20853.33 AUMC(0-t) = 145750.2 AUMC(0-inf) = 249980.2 MRT(0-t) = 8.10613 MRT(0-inf) = 11.98754 ---------------------------- << PK parameter summaries >> Cmax -------------------------------------------------- subject Test Ref Ratio 1 1 1587.0 1694.5 0.937 2 2 1842.0 1471.0 1.252 3 3 2128.0 1790.0 1.189 4 4 1624.0 1469.0 1.106 5 5 1385.5 1550.0 0.894 6 6 1517.0 1751.0 0.866 7 7 1648.0 1623.0 1.015 8 8 1670.0 1944.0 0.859 9 9 1764.0 1680.0 1.050 10 10 1588.0 1493.0 1.064 11 11 1687.0 1222.0 1.381 12 12 1452.0 1587.0 0.915 13 13 1610.0 1337.5 1.204 14 14 1773.0 1643.0 1.079 summary Test Ref Ratio 1 LSMEAN 1662.536 1589.643 1.058 2 S.D. 181.868 186.703 0.158 3 C.V(%) 10.939 11.745 14.913 -------------------------------------------------- Tmax -------------------------------------------------- subject Test Ref Ratio 1 1 2.0 2.00 1.000 2 2 1.5 3.00 0.500 3 3 2.0 2.00 1.000 4 4 2.0 2.00 1.000 5 5 2.0 3.00 0.667 6 6 3.0 2.00 1.500 7 7 2.0 1.50 1.333 8 8 3.0 2.00 1.500 9 9 3.0 2.00 1.500 10 10 2.0 1.50 1.333 11 11 2.0 1.50 1.333 12 12 2.0 3.00 0.667 13 13 3.0 1.75 1.714 14 14 3.0 3.00 1.000 summary Test Ref Ratio 1 LSMEAN 2.321 2.161 1.146 2 S.D. 0.541 0.585 0.368 3 C.V(%) 23.301 27.080 32.146 -------------------------------------------------- AUC0t --------------------------------------------------- subject Test Ref Ratio 1 1 11732.95 13948.263 0.841 2 2 15358.01 12406.444 1.238 3 3 15165.62 15561.213 0.975 4 4 14347.77 11032.475 1.301 5 5 11761.65 13891.200 0.847 6 6 13853.73 14771.475 0.938 7 7 13086.30 13217.425 0.990 8 8 13586.90 13416.225 1.013 9 9 15038.96 12545.775 1.199 10 10 11803.38 13461.075 0.877 11 11 14260.92 9380.250 1.520 12 12 10202.25 14997.700 0.680 13 13 14305.41 9542.325 1.499 14 14 17891.50 15577.788 1.149 summary Test Ref Ratio 1 LSMEAN 13742.526 13124.974 1.076 2 S.D. 1945.507 1994.792 0.251 3 C.V(%) 14.157 15.198 23.309 --------------------------------------------------- AUC0inf --------------------------------------------------- subject Test Ref Ratio 1 1 12396.58 14419.475 0.860 2 2 16272.62 13010.780 1.251 3 3 15660.00 16194.399 0.967 4 4 14976.02 11586.301 1.293 5 5 12390.03 14474.394 0.856 6 6 14345.00 15342.138 0.935 7 7 13636.32 13823.539 0.986 8 8 13915.62 13956.616 0.997 9 9 15845.95 13031.819 1.216 10 10 12551.64 14224.877 0.882 11 11 14939.08 9770.836 1.529 12 12 10656.12 15752.576 0.676 13 13 15257.15 10107.176 1.510 14 14 19868.59 16403.120 1.211 summary Test Ref Ratio 1 LSMEAN 14479.338 13721.289 1.083 2 S.D. 2230.335 2068.855 0.255 3 C.V(%) 15.404 15.078 23.560 --------------------------------------------------- (AUC0t/AUC0inf)*100 --------------------------------------------------- subject Test Ref Ratio 1 1 94.647 96.732 97.844 2 2 94.379 95.355 98.977 3 3 96.843 96.090 100.784 4 4 95.805 95.220 100.614 5 5 94.928 95.971 98.914 6 6 96.575 96.280 100.306 7 7 95.966 95.615 100.367 8 8 97.638 96.128 101.570 9 9 94.907 96.270 98.584 10 10 94.039 94.631 99.374 11 11 95.461 96.003 99.435 12 12 95.741 95.208 100.560 13 13 93.762 94.411 99.312 14 14 90.049 94.968 94.820 summary Test Ref Ratio 1 LSMEAN 95.053 95.634 99.390 2 S.D. 1.811 0.685 1.657 3 C.V(%) 1.905 0.717 1.667 --------------------------------------------------- ln(Cmax) -------------------------------------------------- subject Test Ref Ratio 1 1 7.370 7.435 0.991 2 2 7.519 7.294 1.031 3 3 7.663 7.490 1.023 4 4 7.393 7.292 1.014 5 5 7.234 7.346 0.985 6 6 7.324 7.468 0.981 7 7 7.407 7.392 1.002 8 8 7.421 7.573 0.980 9 9 7.475 7.427 1.007 10 10 7.370 7.309 1.008 11 11 7.431 7.108 1.045 12 12 7.281 7.370 0.988 13 13 7.384 7.199 1.026 14 14 7.480 7.404 1.010 summary Test Ref Ratio 1 LSMEAN 7.411 7.365 1.006 2 S.D. 0.106 0.120 0.020 3 C.V(%) 1.424 1.633 1.992 -------------------------------------------------- ln(AUC0t) --------------------------------------------------- subject Test Ref Ratio 1 1 9.370 9.543 0.982 2 2 9.639 9.426 1.023 3 3 9.627 9.653 0.997 4 4 9.571 9.309 1.028 5 5 9.373 9.539 0.983 6 6 9.536 9.600 0.993 7 7 9.479 9.489 0.999 8 8 9.517 9.504 1.001 9 9 9.618 9.437 1.019 10 10 9.376 9.508 0.986 11 11 9.565 9.146 1.046 12 12 9.230 9.616 0.960 13 13 9.568 9.163 1.044 14 14 9.792 9.654 1.014 summary Test Ref Ratio 1 LSMEAN 9.519 9.470 1.005 2 S.D. 0.143 0.163 0.025 3 C.V(%) 1.506 1.725 2.466 --------------------------------------------------- ln(AUC0inf) --------------------------------------------------- subject Test Ref Ratio 1 1 9.425 9.576 0.984 2 2 9.697 9.474 1.024 3 3 9.659 9.692 0.997 4 4 9.614 9.358 1.027 5 5 9.425 9.580 0.984 6 6 9.571 9.638 0.993 7 7 9.520 9.534 0.999 8 8 9.541 9.544 1.000 9 9 9.671 9.475 1.021 10 10 9.438 9.563 0.987 11 11 9.612 9.187 1.046 12 12 9.274 9.665 0.960 13 13 9.633 9.221 1.045 14 14 9.897 9.705 1.020 summary Test Ref Ratio 1 LSMEAN 9.570 9.515 1.006 2 S.D. 0.152 0.161 0.025 3 C.V(%) 1.585 1.696 2.479 --------------------------------------------------- MRT0inf --------------------------------------------------- subject Test Ref Ratio 1 1 8.297 7.420 1.118 2 2 8.285 8.028 1.032 3 3 7.451 7.996 0.932 4 4 8.038 8.045 0.999 5 5 8.088 7.813 1.035 6 6 7.775 7.694 1.011 7 7 7.711 7.970 0.968 8 8 6.888 7.689 0.896 9 9 8.307 7.739 1.073 10 10 8.584 8.691 0.988 11 11 8.236 7.992 1.031 12 12 7.786 8.532 0.913 13 13 8.845 7.955 1.112 14 14 10.509 8.817 1.192 summary Test Ref Ratio 1 LSMEAN 8.200 8.027 1.021 2 S.D. 0.824 0.397 0.083 3 C.V(%) 10.054 4.951 8.134 --------------------------------------------------- T1/2(z) --------------------------------------------------- subject Test Ref Ratio 1 1 5.528 4.633 1.193 2 2 5.556 5.077 1.094 3 3 4.515 4.866 0.928 4 4 5.052 5.226 0.967 5 5 5.292 5.047 1.049 6 6 4.690 4.848 0.967 7 7 5.147 5.149 1.000 8 8 4.165 4.976 0.837 9 9 5.230 4.976 1.051 10 10 5.699 5.716 0.997 11 11 5.188 5.203 0.997 12 12 5.031 5.317 0.946 13 13 5.601 5.348 1.047 14 14 7.051 5.283 1.335 summary Test Ref Ratio 1 LSMEAN 5.268 5.119 1.029 2 S.D. 0.672 0.265 0.121 3 C.V(%) 12.757 5.185 11.762 --------------------------------------------------- Vd/F --------------------------------------------------- subject Test Ref Ratio 1 1 51.551 37.132 1.388 2 2 39.406 45.039 0.875 3 3 33.274 34.681 0.959 4 4 38.957 52.057 0.748 5 5 49.299 40.242 1.225 6 6 37.732 36.535 1.033 7 7 43.828 42.998 1.019 8 8 34.637 41.153 0.842 9 9 38.190 44.071 0.867 10 10 52.410 46.380 1.130 11 11 40.311 61.465 0.656 12 12 54.556 38.958 1.400 13 13 42.677 61.037 0.699 14 14 40.641 37.248 1.091 summary Test Ref Ratio 1 LSMEAN 42.676 44.214 0.995 2 S.D. 6.746 8.550 0.235 3 C.V(%) 15.808 19.337 23.647 --------------------------------------------------- Lambda_z --------------------------------------------------- subject Test Ref Ratio 1 1 0.125 0.150 0.833 2 2 0.125 0.137 0.912 3 3 0.154 0.142 1.085 4 4 0.137 0.133 1.030 5 5 0.131 0.137 0.956 6 6 0.148 0.143 1.035 7 7 0.135 0.135 1.000 8 8 0.166 0.139 1.194 9 9 0.133 0.139 0.957 10 10 0.122 0.121 1.008 11 11 0.134 0.133 1.008 12 12 0.138 0.130 1.062 13 13 0.124 0.130 0.954 14 14 0.103 0.131 0.786 summary Test Ref Ratio 1 LSMEAN 0.13392857 0.135714286 0.9871429 2 S.D. 0.01524903 0.007021161 0.1022718 3 C.V(%) 11.38594365 5.173487132 10.3603827 --------------------------------------------------- Cl/F --------------------------------------------------- subject Test Ref Ratio 1 1 6.467 5.555 1.164 2 2 4.916 6.149 0.799 3 3 5.109 4.941 1.034 4 4 5.345 6.905 0.774 5 5 6.457 5.527 1.168 6 6 5.577 5.223 1.068 7 7 5.880 5.789 1.016 8 8 5.767 5.732 1.006 9 9 5.059 6.139 0.824 10 10 6.374 5.625 1.133 11 11 5.385 8.188 0.658 12 12 7.520 5.079 1.481 13 13 5.268 7.919 0.665 14 14 4.036 4.882 0.827 summary Test Ref Ratio 1 LSMEAN 5.654 5.975 0.973 2 S.D. 0.855 1.031 0.229 3 C.V(%) 15.124 17.258 23.537 ---------------------------------------------------